Understanding Creatinine and eGFR Results
Why creatinine rises, what a high value can and cannot tell you, and the appropriate next steps.
Last updated: 2026-09-24
Creatinine is a waste product produced by muscle and cleared by the kidneys. When filtration slows, creatinine accumulates in the blood, so a high value can be an early signal — but it can also rise for reasons that have nothing to do with kidney disease.
What can raise creatinine
- Reduced kidney function (CKD or acute kidney injury)
- Dehydration
- Heavy exercise shortly before the test
- A high-protein meal or creatine supplements
- Certain medicines
Sensible next steps
Do not self-treat or pursue unproven remedies. Repeat the test, stay adequately hydrated, and have a clinician interpret the trend together with the eGFR and a urine protein result.
Products marketed as kidney cleanses or detoxes have no evidence of benefit and some are harmful. Discuss any supplement with your treating doctor.
Frequently asked questions
Is a high creatinine always kidney disease?
No. Dehydration, exercise and diet can raise it transiently. A clinician confirms with a repeat test and the eGFR.
Can creatinine be lowered by diet?
Dietary changes should be guided by your stage and lab results under professional advice, not self-directed restriction.